This activity is sponsored by The Movement Disorder Society.

The Movement Disorder Society

This activity is supported by an educational grant from

Schwarz Pharma.

Schwarz Pharma

Washington Convention Center, Washington, DC February 22, 2006

This online CME activity is based on the educational session "Patch Delivery" held at the 2006 World Parkinson Congress in Washington, DC.

Persons who attended the symposium are NOT eligible for AMA PRA Category 1 Credit™ for completing this enduring material. Please note that the course is accredited only for physicians (MD, DO, or equivalent). All other participants receive a certificate of completion.

Intended Audience

This CME activity is designed for clinicians, researchers, postdoctoral fellows, allied health professionals, students, caregivers, and people with Parkinson disease who have an interest in the current research and approaches for the diagnosis and best-care practices of Parkinson disease.

Release Date

December 20, 2006

Expiration Date

December 19, 2007

Term of Offering

This CME activity has a release date of December 20, 2006, and is valid for 1 year. Requests for credit must be received no later than December 19, 2007. After reviewing all of the presentations and completing both the course test and the course evaluation, participants will receive further instruction regarding instantaneous online receipt of credit. For inquiries regarding technical issues with CME/CE or registration, email eMedicine at CME/CE Support. Please direct CME content–related questions to MDS at 414-276-2145 or info@movementdisorders.org.

 

 

Estimated Completion Time

1 hour

Chair

Anthony Lang, MD, FRCP
Movement Disorder Clinic
Toronto Western Hospital
Toronto, Canada

Faculty

Kapil Sethi, MD, FRCP
Medical College of Georgia
Augusta, Georgia

Cheryl Waters, MD, FRCP
Neurological Institute
Columbia University
New York, New York

 

 

Statement of Need

Parkinson disease is a progressive movement disorder that affects nearly 1 million US adults. Approximately 40,000 people are diagnosed with Parkinson disease each year in the United States. Although a cure does not presently exist, surgical and pharmacotherapeutic advances have led to improved treatment options and delivery methods for patients with Parkinson disease.

Activity Purpose

This activity was developed to apprise clinicians of the role of the transdermal patch in antiparkinsonian drug delivery for the treatment of Parkinson disease. Specific disease management concepts, novel delivery methods, and the emerging role of the rotigotine transdermal system in the treatment of patients with advanced-stage Parkinson disease are discussed.

Learning Objectives

After completing this activity, participants should be able to

  • understand the basic neuroscientific principles underlying the continuous delivery approach,

  • discuss expected clinical responses and adverse effects when dopaminergic drugs are administered parenterally,

  • describe the results of the clinical trials of the transdermal dopamine agonist rotigotine in early Parkinson disease, and

  • understand the results of the clinical trial of rotigotine in advanced Parkinson disease.

 

Accreditation/Planning

The Movement Disorder Society (MDS) is accredited by the ACCME to provide continuing medical education for physicians.

Designation of Credit

MDS designates this educational activity for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

Disclosure Policy

MDS requires that CME faculty disclose, during the planning of an activity, the existence of any personal financial or other relationships they or their spouses/partners have with the commercial supporter of the activity or with the manufacturer of any commercial product or service discussed in the activity.

Off-label Discussion

This CME activity may include discussions regarding the use of medications that may be outside of the approved labeling for these products. Physicians should consult the current prescribing information for these products. MDS requires faculty members to disclose that a product is not yet labeled for the use under discussion or to state that the product is still investigational.

Faculty Disclosures and Biographies

Anthony Lang, MD, FRCP
Consultant for Teva Pharmaceutical Industries Ltd., Boehringer Ingelheim, Pfizer, Novartis, Biogen-Idec, Medtronic, and GlaxoSmithKline; receives grants/research support from Medtronic and Novartis; receives honoraria from GlaxoSmithKline, Novartis, and Boehringer Ingelheim; does not discuss unlabeled/unapproved uses of drugs or products in his portion of the presentations.

Dr Lang is a professor of neurology in the Department of Medicine at the University of Toronto in Toronto, Canada. He is also the director of the Morton and Gloria Shulman Movement Disorders Clinic at the Toronto Western Hospital and the Jack Clark Chair in Parkinson Disease Research at the University of Toronto. Dr Lang is also the director of the Division of Neurology at the University of Toronto.

After receiving his training in medicine and neurology at the University of Toronto, Dr Lang completed a clinical research fellowship with Professor C.D. Marsden at King's College Hospital and the Institute of Psychiatry in London, England. In 1982, following his fellowship,  Dr Lang returned to Toronto, where he then developed the Movement Disorders Clinic at the Toronto Western Hospital.

Dr Lang’s research has involved all aspects of Parkinson disease and other movement disorders and can be found in more than 220 peer-reviewed publications in leading medical journals. He is one of the founders of the Parkinson Study Group and the International Movement Disorder Society, and he has served on the executive board of both groups. Dr Lang is a past Co-Editor-in-Chief of the journal Movement Disorders.

Kapil Sethi, MD, FRCP
Consultant for GlaxoSmithKline, Boehringer Ingelheim, Valeant, and Novartis; has ownership interest in Elan, Merck, and Pfizer; and does not discuss unlabeled or unapproved uses of drugs or products in his presentation.

Dr Sethi is a professor of neurology at the Medical College of Georgia in Augusta. He also serves as director of the Movement Disorders Clinic and the National Parkinson Foundation Center of Excellence and as a staff physician at the Augusta Veterans Affairs Medical Center.

An author of numerous reviews, abstracts, book chapters, and journal articles, Dr Sethi’s work is published in numerous peer-reviewed publications, including the Journal of the American Medical Association, Neurology, and Movement Disorders.

With research interests in Parkinson disease, restless legs syndrome, and cervical dystonia, Dr Sethi has participated as principal investigator in numerous clinical trials and research studies. He is frequently invited to lecture and has held visiting professorships at Albany Medical College, the University of Virginia, and the University of Missouri, among others.

Dr Sethi is a fellow of the American Academy of Neurology and the Royal College of Physicians and a member of the American Neurological Association, the Movement Disorder Society, and the American Association of Physicians from India.

Dr Sethi received his medical degree from Christian Medical College, Ludhiana, India. He completed a residency in internal medicine at the Post Graduate Institute of Medical Education and Research, Chandigarh, India, where he also received fellowship training in neurology. Dr Sethi continued his medical education by completing a research fellowship in neurology at the Charing Cross Group of Hospitals and Medical School in London, England. In addition, he was a registrar in neurology at the Welsh National School of Medicine at Morriston Hospital and completed a neurology residency at the Medical College of Georgia.

Cheryl Waters, MD, FRCP
Receives honoraria from GlaxoSmithKline, Boehringer Ingelheim, and Novartis; does not discuss unlabeled/unapproved uses of drugs or products in her presentation.

Dr Waters is a professor of clinical neurology and chief of Clinical Practice and Services, Division of Movement Disorders at Columbia University in New York, New York. She has been involved in research on the genetics and treatment of Parkinson disease and has been an investigator in numerous studies involving a variety of new medical and surgical treatments.

Born in Toronto, Canada, Dr Waters received her master  of pharmacology degree from the University of Toronto, where she studied dopamine receptor function with Philip Seeman. She completed medical school at the University of Toronto and an internship at the University of Chicago, and then returned to Toronto to study internal medicine and neurology and to complete a fellowship in clinical pharmacology. She next moved to California, where she developed the Movement Disorder Program at the University of Southern California before moving to New York in 1999.

Dr Waters was named the first Albert B. and Judith L. Glickman Professor of Clinical Neurology at Columbia University. She has authored numerous articles and book chapters and has 1 book in its third edition.

Instructions to Participants

Course participants must view all presentations and complete both the course test and the course evaluation in order to receive CME credit. No fees are charged to participate in the program or to receive the certificate. Full instructions are available on the user instructions page.

Disclaimer

The opinions expressed herein are those of the faculty and do not necessarily represent the views of the grantor, provider, or publisher. Please review complete prescribing information of specific drugs or combinations of drugs, including indications, contraindications, warnings, and adverse effects, before administering pharmacologic therapy to patients.

Medicine is a constantly changing science, and clearly established therapies are not always available for every condition. New research findings necessitate continual changes in drug and treatment therapies. Reasonable efforts have been made to provide up-to-date, accurate information that is within generally accepted medical standards at the time of publication. However, as medical science is ever evolving, and human error is always possible, the grantor, provider, and publisher (or any other involved party) do not guarantee total accuracy or comprehensiveness of the information in this article, and they are not responsible for omissions or errors, or the results of using information provided in this course. Participants should confirm the accuracy of the information in this activity from other sources. In particular, all drug doses, indications, and contraindications should be confirmed in package inserts.

Content Ownership Statement

The content of this enduring educational activity has been generated from the 2006 World Parkinson Congress and is therefore the property of the Movement Disorder Society. No part of this material may be reproduced in any form or by any means without the prior written permission of the Movement Disorder Society.

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